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What Is the Current Status of Hepatitis B Virus Viro-Immunology?
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Home / Blog / What Is the Current Status of Hepatitis B Virus Viro-Immunology?

What Is the Current Status of Hepatitis B Virus Viro-Immunology?


What Is the Current Status of Hepatitis B Virus Viro-Immunology?

KEY POINTS

  • Adaptive immune responses play a crucial role in antiviral protection during the resolution of acute hepatitis B.
  • The natural course of hepatitis B virus (HBV) infection is associated with the evolution of the host immune response.
  • In the context of the recently reviewed stages of chronic HBV infection, the previously called “immune tolerant” phase has been renamed “HBeAg 1 chronic infection,” because
  • HBV patients in this phase have been shown to be immune active.
  • In patients with chronic HBV infection, virus-specific T and B cells are dysfunctional.
  • Different factors contribute to the immunologic impairment in chronic HBV infection including the prolonged exposure to viral antigens, upregulation of co-inhibitory receptors, T-cell intracellular pathways defects, and the multiple regulatory mechanisms active within the liver.

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