A multi-analyte cell-free DNA–based blood test for early detection of hepatocellular carcinoma

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WHO:

Dr. Gish is a Hepatologist specializing in all forms of liver disease, liver cancer and liver transplant. Dr. Gish has partnered with TeleMed2U to provide telemedicine consultative services for patients with liver disease.

WHAT:

TeleMed2U is a telemedicine-based multi-specialty clinical practice increasing access to specialist providers providing, “healthcare anywhere and everywhere.” The telemedicine consultation will be conducted through our HIPAA and HITECH compliant platform. Connectivity testing will be done in advance to ensure you can connect via our telemedicine platform. Following the consultation, a clinical note will be provided including a summary of your liver consultation with Dr. Gish and his consultative recommendations.

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Payment will be processed through an online secure transaction portal. The fees for consultative services are:

Initial 60 minute consultation per patient: $500.00
Follow Up 30 minute consultation per patient: $300.00

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If you’d like to continue, please click Next to complete the form and we will contact you to schedule connectivity testing. During the test you will have the opportunity to determine the method of providing medical records, discuss appointment availability as well as discuss any additional questions that you have. If you are a healthcare facility interested in services, please complete the form and we can discuss the options that are right for you and your patients.

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A multi-analyte cell-free DNA–based blood test for early detection of hepatocellular carcinoma

Mar 4, 2022

A multi-analyte cell-free DNA–based blood test for early detection of hepatocellular carcinoma

Mortality of liver cancer, with hepatocellular carcinoma (HCC) as the major histological type, has substantially increased over the past two to three decades in the United States and worldwide, and its incidence is projected to continue to increase over the next decade.[1–3] HCC prognosis remains dismal (5-year survival <15%) due to frequent diagnoses at late, noncurable stages.[4,5]

To increase HCC tumor detection at earlier stages that are more amenable to curative treatment, practice guidelines recommend semi-annual HCC surveillance using ultrasound with or without serum alpha-fetoprotein (AFP) for high-risk populations.[6–8] However, the suboptimal performance of current HCC surveillance tests hinders effective early tumor detection. The sensitivity of ultrasound for detecting early-stage HCC is only 45%, and a systematic review and meta-analysis study has suggested that the improvement to ultrasound by adding AFP is limited to only 63%.[9] Additionally, the performance of ultrasound is reduced by various factors such as obesity, which is sharply increasing globally.[10,11] Thus, HCC surveillance tests with superior performance are urgently needed. In an effort to improve HCC detection, the GALAD score was developed by combining age, sex, AFP, Lens culinaris agglutinin-reactive AFP (AFP-L3%), and des-gamma-carboxy prothrombin (DCP).[12] The GALAD score has shown superior HCC detection performance compared with AFP, but there is room for improvement,[13,14] indicating the still unmet need for HCC surveillance tests with substantially improved performance characteristics.

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