Development and validation of a biomarker index for HCC treatment response
Telemedicine Consult - Dr. Gish
Schedule Telemedicine Consult with Dr. Gish

Development and validation of a biomarker index for HCC treatment response

Development and validation of a biomarker index for HCC treatment response

Abstract
Background:
Serum AFP-L3%, AFP, and DCP are useful biomarkers for HCC detection, but their utility in assessing treatment response remains unknown. We aim to evaluate the accuracy of a biomarker model in the detection of posttreatment viable tumors.

Methods:
For model derivation, recipients with HCC undergoing liver transplant from 2018 to 2022 who had biomarkers collected within 3 months before transplant were included. We developed a generalized linear model for detecting posttreatment viable tumors with the 3 biomarkers as covariates, which we termed the “LAD Score.” An independent cohort of 117 patients with HCC was used for external validation.

Read Article


Metadata