Gastrointestinal and Liver Manifestations of COVID-19 - Updated
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Gastrointestinal and Liver Manifestations of COVID-19 - Updated

Gastrointestinal and LiverManifestations of COVID-19
GI/Liver Pathogenesis – Possible Explanations

  • During the SARS-CoV outbreak of 2002-2003, up to 73% of patients  had diarrhea, generally within the first week of the illness.
  • Covid-19 has strong affinity for angiotensin-converting enzyme 2  receptor which is located in multiple human cell types, including  enterocytes in the ileum and colon, hepatocytes and cholangiocytes.
  • The binding efficiency is thought to be stronger for SARS-CoV-2 than  the SARS-CoV-1 outbreak of 2002, which could likely explain its high  rate of transmission to others.
  • The binding of virus to primary intestinal epithelial cells also raises  the prospect of fecal-oral transmission, which is as of yet  unconfirmed for SARS-CoV-2.

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