Viral Hepatitis - Best of Digital ILC
Telemedicine Consult - Dr. Gish
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Viral Hepatitis - Best of Digital ILC

Viral Hepatitis - Best of Digital ILC 2020

**Hepatitis B: translational **

  • Preclinical assessment of capsid assembly modulators of varying potency revealed a novel class of picomolar-acting CAMs inducing neither significant HBcAg cytoplasmic retention nor adverse interactions with HBcAg-specific adaptive immunity
  • Serum and intrahepatic HBV markers and HBV-specific CD8 T cell responses after nucleos(t)ide analog therapy discontinuation in HBeAg-negative chronic hepatitis B patients
  • Targeted long read sequencing reveals the comprehensive architecture and expression patterns of integrated HBV DNA in CHB  liver biopsies

Hepatitis C elimination

  • Population-level hepatitis C cascade of care among men who have sex with men in British Columbia, Canada
  • Hepatitis C infection in the Spanish prison system. Elimination is a dream at our fingertips

HCV: long-term management

  • Profiling of routine serum parameters and AFP evolution in cirrhosis following HCV eradication for stratification of HCC risk: a trajectory clustering analysis from the ANRS CO12 CirVir cohort
  • Virological characterization of patients with chronic hepatitis C and failure to a glecaprevir/pibrentasvir or voxilaprevir/velpatasvir/sofosbuvir treatment in the international SHARED collaboration

Viral hepatitis A, B, C, D, E: virology

  • Hepatitis B virus core protein variants observed in a first-in-human placebo-controlled study of a core protein inhibitor
  • Targeting hepatitis B virus with CRISPR/Cas9 approach
  • Delineating HBV transcripts from integrated viral DNA using target enrichment and long read sequencing

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